1 2 Transient firing of dorsal raphe neurons 3 encodes diverse and specific sensory , motor and reward events 4 5

نویسندگان

  • Sachin P. Ranade
  • Zachary F. Mainen
چکیده

5 Sachin P. Ranade and Zachary F. Mainen * 6 7 Cold Spring Harbor Laboratory 8 1 Bungtown Road 9 Cold Spring Harbor, NY 11724 10 11 Champalimaud Neuroscience Programme 12 Instituto Gulbenkian de Ciência 13 Oeiras, Portugal, P-2781-901 14 15 16 17 Running Title: Diversity and specificity of raphe transients 18 19 20 * To whom correspondence should be addressed 21 Phone: +351 214464533 22 E-mail: [email protected] 23 24 Articles in PresS. J Neurophysiol (August 26, 2009). doi:10.1152/jn.00507.2009

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Transient firing of dorsal raphe neurons encodes diverse and specific sensory, motor, and reward events.

Serotonin (5-hydroxytryptamine [5-HT]) is known to influence a wide range of behaviors and physiological processes, but relatively little is known about events that trigger 5-HT release. To address this issue, we recorded from neurons in the dorsal raphe nucleus (DRN) in rats performing an odor-guided spatial decision task. A large fraction of DRN neurons showed transient firing time locked to ...

متن کامل

Dorsal Raphe Neurons Signal Reward through 5-HT and Glutamate

The dorsal raphe nucleus (DRN) in the midbrain is a key center for serotonin (5-hydroxytryptamine; 5-HT)-expressing neurons. Serotonergic neurons in the DRN have been theorized to encode punishment by opposing the reward signaling of dopamine neurons. Here, we show that DRN neurons encode reward, but not punishment, through 5-HT and glutamate. Optogenetic stimulation of DRN Pet-1 neurons reinfo...

متن کامل

Optogenetic Activation of Dorsal Raphe Serotonin Neurons Enhances Patience for Future Rewards

Serotonin is a neuromodulator that is involved extensively in behavioral, affective, and cognitive functions in the brain. Previous recording studies of the midbrain dorsal raphe nucleus (DRN) revealed that the activation of putative serotonin neurons correlates with the levels of behavioral arousal [1], rhythmic motor outputs [2], salient sensory stimuli [3-6], reward, and conditioned cues [5-...

متن کامل

Reward processing by the dorsal raphe nucleus: 5-HT and beyond.

The dorsal raphe nucleus (DRN) represents one of the most sensitive reward sites in the brain. However, the exact relationship between DRN neuronal activity and reward signaling has been elusive. In this review, we will summarize anatomical, pharmacological, optogenetics, and electrophysiological studies on the functions and circuit mechanisms of DRN neurons in reward processing. The DRN is com...

متن کامل

Serotonergic neurons signal reward and punishment on multiple timescales

Serotonin's function in the brain is unclear. One challenge in testing the numerous hypotheses about serotonin's function has been observing the activity of identified serotonergic neurons in animals engaged in behavioral tasks. We recorded the activity of dorsal raphe neurons while mice experienced a task in which rewards and punishments varied across blocks of trials. We 'tagged' serotonergic...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2009